Resident Evil: Revelations is a survival horror game that restores elements of the series' nature, as opposed to the survival action of Resident Evil 5. The game features a single-player mode where the player must complete a series of episodes that involve solving puzzles and defeating enemies, and a multiplayer mode where players may fight their way through altered single-player scenarios.

Set shortly after the events of Resident Evil 4, the game follows counter-terrorism agents Jill Valentine and Chris Redfield as they try to uncover the truth behind a bio-terrorist organization that plans to infect the Earth's oceans with a virus.