Resident Evil 7: Biohazard is the first game of the Resident Evil series to switch from 3rd-person to fully 1st-person perspective. A complete refresh of gameplay systems simultaneously propels the survival horror experience to another level. It is as much horror as it is survival, boosting up scare elements and minimizing downright shooting action. The game allows use of Sony's PSVR Headset to play in VR mode.

Resident Evil 7: Biohazard is set in mid-2017 somewhere in the southern United States after the dramatic events of Resident Evil 6. The game features a new protagonist named Ethan Winters, a civilian searching for his missing wife Mia which leads him to a derelict plantation mansion occupied by an infected family.