Resident Evil 5 is the seventh video game in the Resident Evil series. It features similar gameplay to Resident Evil 4 utilizing the same over the shoulder view, but this time the environment plays a significant role. The player is now dependent on his partner more than in older games. When the partner's health bar drop down to 0, he will enter the dying stage where the health bar will flash red and gradually lower as he stays like this. Resident Evil 5 also features new types of enemies called Majini and mostly are of African descent.

The Umbrella Corporation and its crop of lethal viruses have been destroyed and contained. But a new, more dangerous threat has emerged. Years after surviving the events in Raccoon City, Chris Redfield has been fighting the scourge of bio-organic weapons all over the world. Now a member of the Bioterrorism Security Assessment Alliance (BSAA), Chris is sent to Africa to investigate a biological agent that is transforming the populace into aggressive and disturbing creatures. Joined by another local BSAA agent, Sheva Alomar, the two must work together to solve the truth behind the disturbing turn of events.