Resident Evil 6 is the ninth video game installment in the Resident Evil series. It continues the struggle against zombies infected by the new highly virulent C-virus. The game uses the same over-the-shoulder view as Resident Evil 4 and Resident Evil 5, however with a new gameplay mechanic that allows players to slowly move while shoot. Players can select between three scenarios featuring multiple characters and intertwined storylines, and within these scenarios both stories and action cross paths. At key moments during the game, up to four players can join together online to tackle a specific situation, with some stages seeing the usual partnerships swapped to further increase the depth of gameplay.

The game takes place over a period of at least six months from December 2012 to June 2013, over fifteen years after the US Government's destruction of Raccoon City, and takes place in various places around the world.