"Two puzzle game juggernauts collide as Tetris, one of the largest-selling and recognized brands in gaming history, and Puyo Puyo from SEGA have combined to create a fun-to-play, fast-paced, competitive party game like no other! The game has tons of different styles of gameplay – from the single-player Adventure and Challenge modes to the ferocious competition of the up-to-four player Arcade modes. There's plenty of Tetris/Puyo variety, even an in-game Shop where players can unlock new characters, new skins for Puyos and Tetriminos, new backgrounds and more."

The main story follows the characters being affected with a series of events that foreshadow the merging worlds of both Puyo Puyo and Tetris. Similar to Puyo Puyo 7, the story is divided into seven acts, with ten playable episodes. These episodes consist of different game modes, which may be played with or without an opponent. However, playable characters are locked, meaning the player can only use the character relevant to that part of the story, including characters that have not yet unlocked.