Puyo Puyo!! Quest, not to be confused with Puyo Puyo!! Quest Arcade or Puyo Puyo Quest (the RPG-styled quest mode in Puyo Puyo Box), is a Puzzle RPG spin off of the Puyo Puyo series. The game features puzzle elements that is never before seen in the franchise, and uses a card system similar to other mobile RPG such as Puzzle & Dragons. The game is also renowned for reviving many older characters from across the franchise, and introducing many new original characters.

The game offers an experience similar to several puzzle role-playing games like Puzzle & Dragons, with a playability different from traditional Puyo Puyo games. The player deletes five types of "Puyo" (red, blue, green, yellow and purple) on a 6x8 square matrix puzzle screen by finger swiping. When four or more puyos of the same color are connected vertically or horizontally, they disappear and their actions are linked to make an ally card attack, corresponding to the color of each card. The board is constantly filling as the player deletes Puyos.