It is a brand new year at the Duel Academy and the students are excited to start school. You are placed in the Slifer Red Dorm, and soon after the start of the school year, strange things begin happening. As soon as these odd occurrences begin, you start hearing the voice of spirit duelist. This spirit is a good spirit and will help you duel and solve the mysteries surrounding the Duel Academy. Head to head worldwide dueling via the Nintendo Wi-Fi Connection. Includes over 1,500 cards. Create and edit the look of your character. Each game includes three exclusive trading cards.

The player is on a ship, on their way to Duel Academy, with their friends Jaden Yuki and Syrus Truesdale. The player is placed in the Slifer Red dorm, and soon after, strange things begin to happen. As soon as these odd occurrences begin, you start hearing the voice of a duel spirit. This spirit is a good spirit and will help you duel and solve the mysteries surrounding the Duel Academy.

The story loosely follows the events of the anime, only the player takes place of Jaden's duels. Such as Dimitri stealing Yugi's Deck, and the player getting it back. The game mostly covers the anime, from the beginning to the Dark Zane arc. Because the game is based on the anime, some major and minor characters will appear. It also includes a lot of characters exclusive to Spirit Caller; they are featured as minor characters. You will later duel all 7 Shadow Riders and other parts of Season One then you will enter a tournament after.