Yandere Simulator 2: The Sequel is a Visual Novel that takes place after the story of the official Yandere Simulator Game, when Yandere-Chan finally killed all of her rivals.

After Yandere-Chan (Ayano Aishi) finally eliminates her rivals, it is time for her to meet her Senpai (Taro Yamada), become his friend, confess her feelings for him, and then, they would be happy forever. Meanwhile, her mother, Ryoba Aishi, is hunting The Journalist, the man who can destroy the entire Aishi Family knowing Ryoba's darkest secret. But, at the same time, there is one last mysterious threat left for Yandere-Chan. Who is it? Will Yandere-Chan defeat this last threat? Will she and Senpai live happily ever after?