Get ready to embody the soul of a 100-foot tall monstrosity as you clash with opponents in thriving cities, run rampant through bustling streets, pulverize opponents with body slams and fight off military defenses. War of the Monsters enables you to re-live your favorite monster movies with ten different creatures engaging in all out carnage. Ten fully interactive environments offer numerous weapons, including steel girders, radio antenna, moving vehicles, building rubble, army tanks and more. Clobber opponents with thunderous uppercuts, hand-to-hand weapons and destructive special attacks. Use huge hunks of debris as a shield, topple buildings onto your foes or pick up and throw tanker trucks like toys. Take advantage of environmental attacks such as tidal waves and earthquakes to defeat your opponent and claim total domination.

The plot is set in the 1950s where a fleet of alien flying saucer warships invade the Earth, causing massive damage. The scientists of the world's nations manage to create a series of secret weapons, which, when activated, let loose shock waves that short-circuit the saucers and cause them to crash. Unfortunately, each flying saucer is fueled by a green radioactive liquid, which leaks out from destroyed crafts as they crash. Through this, the fuel infects creatures, humans, and robots, creating a war between the monsters. The player acts as one of these monsters and battles against the rest in fictional cities across the globe and the remaining UFOs.