Thistlemine is a puzzle RPG that tells a story about the work that takes place within an Anomalis Exclusion Zone – a hostile environment where space and time are warped, and the thick miasma suffocates those trapped within.

Long ago, the world was devastated by the miasma, rendering the lands into a poisoned wasteland. Alongside the miasma came the "Anomalis", sentient lifeforms created by the miasma to perpetuate its existence.

The game is set in an Anomalis Exclusion Zone, a place where a thick miasma bends both space and time, slowly growing and tearing the fabric of reality. Within await the native anomalis, hostile stalkers, and the many mutated by the miasma.

Among those that venture into the exclusion zone are members of the Thistlemine Excavation Corps; a military faction with the sole responsibility of securing and preventing the growth of exclusion zones.

As Noa, a young member of the Excavation Corps, you will venture in this hostile environment. Inside you will navigate a dreamlike garden, fight the anomalis, find artifacts, and try to survive until a chance to escape presents itself.