"The Last Experiment" is a base-defense strategy game. Your base starts as a small shelter, and your mission is to conquer a devastated, monster-infested Earth set in the year 2805. You’ll attempt this by planting radiation-resistant crops while deploying unique combinations of passive-defense tools—designed by the player—to fend off the encroaching "Fleshvine." Your goal is to prevent it from breaching your territory, killing your creatures, and infiltrating the remnants of humanity at your base.

After the technological singularity, the world lies in ruin. The surface is overrun by a parasitic species, devouring all it touches. An underground team of scientists works to develop resistant lifeforms to reclaim the world – but they need a brave scout to face the dangers above.