In Van Helsing III, the civil war is over in Borgovia, but the future looks grim. The city of weird science is in ruins, squabbling factions and criminals fight for power and a strange cult prophesizes the coming of "The end of times."

A wave of uncanny events shakes the land, and it's all connected to a mysterious creature, a former ally turned into a fearful arch-villain. Which means that Van Helsing will do what he does best: He wields weapons, prepares his deadly tricks, and hunts down the most dangerous monster who has ever lived… and this time it's personal. He's prepared to do anything to achieve his goal, even to face the darkest secret about the birth of the modern Borgovia.