Talisman: The Horus Heresy is a digital board game based on the Talisman rule system and set in the Warhammer 40,000 universe, during the cataclysmic events of the Horus Heresy.

Up to four players will be able to take control of one or more of the galaxy's greatest heroes or most notorious villains. Taking the side of either traitor or loyalist, these Warlords will form vast companies of Space Marines, battalions of tanks and battlefleets of Spacecraft. They are the most powerful beings in the Galaxy and their followers are legion.