A prequel to Space Quest 2, but set before Space Quest 1, it is written in AGI and uses a parser input system similar to that of Space Quest 1 and 2.

SQ0 offers fans an untold tale of Roger Wilco from the days before Space Quest 1, as our hero finds himself posted aboard Labion Orbital Station 10, a Class 3 Cloning Facility. Unfortunately, it appears that a mysterious someone (or something) has murdered all of Roger's fellow crew mates during one of his famous supply-closet naps.

Join Roger as he escapes the station, travels to Labion for the first time, manages to die in literally dozens of creative new ways as he struggles to figure out just what happened aboard LOS10 and—if he plays his cards right—save the universe from a fate too terrible to mention.