As you begin a game of Sleuth a murder has just been committed. Your job is to mingle with the house guests and to search the contents of the house until you feel you have solved the crime. Every game of Sleuth is different so you must fully explore the house each time that you play. As your investigation proceeds the murderer will begin to grow suspicious and will most likely start plotting your demise. If you have not figured out who the murderer is by this point in the game, your chances of survival are slim.

In the tradition of the famous board game Clue/Cluedo, a murder has been committed in a lavish mansion and it is now up to you to investigate the crime and expose the murderer.