Sicko Sanctum features fast classic FPS combat in horde based surrealist levels. With unlimited upgrades become overpowered and triumph over powerful enemies. Defeat the malevolent Martation Prime or play infinitely, the Sicko Sanctum doubles as a rogue-like and score attack shooter.

Despite Griffith's efforts to get to the bottom of the Monolith of Foolery and finally obtain forgiveness for the treacherous crimes they've comitted they have been expelled from life by Martation. Now Griffith is relegated to a codified hell, and you play their fight through it.