Shooters Solitude is a classic bullet hell game in which the player pilots a small ship tasked with eliminating successive waves of enemies that appear from the top of the screen. Each level concludes with a challenging boss encounter.

The game's weapon system is based on a color-coded cross-grid mechanic. Defeating enemies of a specific color increases the power of the corresponding weapon, and the player can switch between weapon types at any time. A combo system enhances gameplay by allowing the player to gain additional power and speed depending on the combos executed. Movement is supported in eight directions using the keyboard, offering more control than the typical four-directional schemes. The game also supports joystick input.