Zettai Zetsumei Toshi 2: Itetsuita Kiokutachi is an action adventure survival game and is the sequel to Zettai Zetsumei Toshi. The game follows six characters as they try to escape a city that is being flooded by torrential rains. Players must think on their feet and utilize creative survival skills to have any hope of seeing their family again. Body temperature and health decrease when players are wet or in cold weather too long. They must find places to warm themselves and gather food, and find dry clothes or make them. In the end, players must run, climb, jump, and crawl their way out of this devastated city, while constantly trying to piece together information from emergency broadcasts and other victims of the disaster. The choices that the players make within the game affects the main storyline and dialog, and ultimately the ending of the game.

In December, 2010, the thriving city of Del Ray, built around the Hudson River, is preparing to commemorate the opening of Geo City, a massive underground metropolitan complex underneath Del Ray designed to be the safest and most advanced city ever built. The Mayor of Del Ray holds a conference in Geo City to celebrate its success, but several days of heavy rainfall causes Del Ray to issue a precautionary warning to evacuate after the Hudson River's water levels rise beyond cautionary levels, creating a prelude to a major disaster.

Players must think on their feet and utilize creative survival skills to have any hope of seeing their family again. Body temperature and health decrease when players are wet or in cold weather too long - they must find places to warm themselves and scrap together meals from whatever they can find. In the end, players must run, climb, jump, and crawl their way out of this devastated city, while constantly trying to piece together information from emergency broadcasts and other victims of the disaster.