Radilgy is a vertical shooter with its own unique graphical design taking inspiration from anime and the look of cel-shaded graphics.

The story follows a schoolgirl named Shizuru Kamigusa, who is allergic to radio waves. Her father works for a company developing a remedy for the condition, but a terrorist group led by Ruki Michima takes over their building. Shizuru mans a flying mecha to save her father and the medicine from the terrorists.