Psychic Force 2012, the sequel to Psychic Force, is a one-on-one fighting game with a twist. The matches take place inside a giant floating cube. You are able to fly, using your psychic abilities, around a 3D arena with six walls. Each of the ten available characters, Might, Regina, Wendy, Emilio, Setsuna, Patty, Gudeath, Genshin, Carlo, and Gates, are controlled with three buttons: guard, weak attack and strong attack. The effect varies with the distance. Next to the regular life meter, there is also a power meter. By using special moves, the meter is drained and your moves are limited. It is possible to recharge, and the capacity of the power meter expands when you lose a lot of health.

Additionally, each fighter has its own unique moves, energy attacks and a weapon, which they use, mid-flight, to pummel their opponent. There are three main game modes: training, versus and a story mode using static anime-inspired images and in-engine cut scenes to tell the story. The story centers around two groups of psychics with differing ideals about co-existence with humans. In the middle of this are several neutral psychics with ties to members in either group.

Taking place two years after the events of Psychic Force, the sequel finds the world caught in the crossfire between two factions who vie for control over the Earth. Upon returning after his fateful past battle against his old friend Burn Griffiths, Keith Evans resurrects NOA as Neo NOA and once again resumes his conquest of establishing a utopia for united Psychiccers. Richard Wong, who had broken away from NOA, establishes his own group of Psychiccers known as "The Army" and seeks to eliminate Neo NOA in an attempt to conquer the world. As the two groups fight for control over the fate of the Earth, independent Psychiccers who find themselves being drawn into the conflict seek to hunt down members of Neo NOA and The Army in an attempt to find the truth and help locate their missing family and friends.