Pokémon Team Rocket Blast Off is one of three Flash-based computer games that were developed for the 10th Anniversary Perdue Farms promotion. The other two games are Pokémon Poké Ball Launcher and Pokémon Seek & Find. Pokémon Team Rocket Blast Off is a simple game in which players have to catch falling Pokémon.

The game consists of Ash and May holding a tarp to catch the Pokémon tossed by the Team Rocket trio from their balloon. They drop both Pokémon and sandbags. The player moves Ash and May by moving the mouse. Pokémon may drop at different speeds and angles, and if their path hits a screen border, they will bounce off of it. They will also bounce back up in the air if they hit the edge of the tarp.

Catching a Pokémon earns one point, but missing a Pokémon or catching a sandbag causes a deduction of points. Points are represented by Poké Balls that fill a bar on the left-hand side, and will never be negative. Levels 2 and 3 also have time limits.

The game is won once the player obtains nineteen points. Winning the game results in Team Rocket's balloon bursting, causing the trio to blast off.