Pixel P.I. is a detective game that allows you to ask questions by typing in order to unlock answers from witnesses or suspects.

It follows Pixel, a hacker detective who lost her recent memories and is going over past police cases trying to find any clue about her missing past.

Pixel wakes up in her house, finding a robot companion she doesn't recognize, and soon realizing she lost her recent memories. She panics and looks for information on her digital devices, realizing all her recent files and records have been deleted.

The robot companion, named Ethan, tries to help her, but Pixel doesn't trust him, considering she didn't like robots last she remembers. Ethan claims he also has his memories fuzzy.

In this context Pixel finds a physical notebook she kept hidden in case of being hacked, that contains a lot of her passwords and important information. She notices the last entry is a list of police case ID's that she doesn't remember writing, so she decides to review those cases trying to find information on her recent past.