Path of Kami follows the spirit of recently-deceased Japanese wolf Kazeyo as he navigates the trials of the Mortal and Spirit World through puzzles. He is accompanied by Wisp, a wolf spirit embodying both his mother and his more distant ancestors, who is there to guide him on his journey.

Kazeyo dies in a snowstorm and awakes as a spirit. With his mother by his side, he travels to the spirit world in order to ascend to the afterlife.