Otaku's Adventure is an anime-style AVG that tells the story of an Otaku who has been single since birth and craves to be loved. After a romantic encounter with three charming girls, your life will take an unexpected turn: to go on a run-away adventure with Waifu, an outer-space travel with Gohard, or an exploration in a fantasy world.

The story tells of an Otaku who has been single for many years and thirst for love. While he inadvertently embarks on a fantastic journey, he eventually wins girls' love. The game combines storytelling with alternative TAKAGISM, and includes a variety of mini-games, as well as different types of battles, which brings players different experience and fun in compare to previous games.