One Piece Odyssey is an RPG that puts players in control of Luffy and the other Straw Hat Pirates in an open world. You can travel around an island embarking on quests, exploring dungeons, solving puzzles and battling creatures in turn-based combat. During fights, the crew is divided up between active members and reserve members. All characters receive EXP, regardless of whether they are part of the active party or not.

The famed pirate Monkey.D.Luffy and his Straw Hat Crew are sailing across the New World in search of the next island and the next adventure that awaits them. But during their voyage they are caught in a storm and shipwrecked. They find themselves washed up on a lush tropical island surrounded by constantly raging storms. Separated from his crew, Luffy sets off on a grand new adventure to find his friends and escape the island.