Nurse Story features a dating adventure set in a metropolitan hospital where the player's character arrives in the first of december as a patient.

The protagonist of the story is hospitalized and needs to stay for three months in a hospital. What to do during all that time, worry about getting better? Nope, walk all over the hospital and try to woo the nurses and hospital staff. First part of the game centers on your trying to win the heart of the woman of your choice in a typical love simulation style. Second part then turns into a romantic visual novel story.