Mushihimesama is a manic shooter developed by Cave and released by Taito in 2004. It was ported to the PlayStation 2 in 2005 and iOS in 2011. An Xbox 360 port was released in May 2012 (with ver1.5 as first print DLC). A significantly changed "version 1.5" was released to arcades in 2011. The game has an insect theme as all of the enemies resemble various insects such as beetles and butterflies. The game is set in various forest environments. It received a sequel in 2006, known as Mushihimesama Futari, and a spin-off iOS game entitled Mushihimesama Bug Panic.

Huge insect-like creatures called Koju roam the forest outside the village of Hoshifuri. When Reco's people fall to a mysterious sickness, the young princess decides to leave the village and meet the God of the Koju, who may provide a cure. Riding her faithful Golden Beetle friend Kiniro, Reco must traverse the wilds, braving the hostile landscape and the aggressive Koju beasts on her journey through the Shinju Forest.