MIND: Path to Thalamus is a First Person Puzzler that throws you into a fantastic and surreal environment. You will bend the natural elements to your will in order to progress in this emotive, mindbending tale.

Mind begins with the protagonist asking himself, "How many times will I kill her?" The game then fades to Menorca, Spain, where a massive tornado approaches the town where the protagonist and his daughter, Sophia, are staying. Hinting that this is a flashback, the protagonist races to the house, calling Sophia's name, but loses consciousness when the tornado reaches the house.

The protagonist soon finds himself exploring a dream-like world, in which he solves puzzles within the environment and gives various monologues. Early on, the protagonist glimpses a massive tree, which he dubs "the Thalamus", and decides to head there, thinking he might find Sophia.