Midnight Resistance is a side-scrolling action shooting game produced by Data East for the arcades in 1989. The game was ported by Data East to the Sega Mega Drive in 1990 and by Ocean Software to various home computer platforms during the same year. The game is set in a dystopian future where the player controls a member of a resistance movement who goes on a mission to rescue his kidnapped family from a mad scientist.

In the arcade version, two nameless brothers are on a mission to rescue their family from an entity known as King Crimson.

In the Sega Genesis/Mega Drive version, the main character is Johnny Ford who's a member of an operative group who shuts down drug cartels in South America. After completing his last mission, Johnny returned home only to find it in shambles, and he sees a note in which King Crimson kidnapped his entire family. The reason for the abduction is that Johnny's father, Malcolm Ford, was developing a serum which could help people break their addictions to all narcotics. Since the government is unable to help Johnny, he sets off on his own to rescue his family and destroy King Crimson's empire of evil for good.