You're a microsurgeon, and your patient is in critical condition! First you need to examine the patient's medical chart to find out what's wrong, and which conditions are the most critical. Now to save the patient, you control a robot probe which can be used to administer aspirin, antiseptic, or ultrasonics to clear up the problem. You should clear up the most critical conditions first, then move on to the less serious areas to ensure your patient survives. Your probe should navigate through the veins, arteries, and lymph; if you guide the probe outside these areas, it's movement will slow down and swarms of white blood cells will attack it, depleting the limited energy supply. There are 197 different patients you need to help, each with different ailments.

Microsurgeon was among 240 video games selected to be included in "The Art of Video Games" exhibit at the Smithsonian Institution in 2012.

A tanker carrying hazardous material was damaged during an accident, allowing the gas inside to escape. Those exposed to the fumes begin to suffer a range of immune disorders, such as rampant bacterial infections, rapidly growing tumors, and widespread tar deposits in the lungs. Patients are being rushed to Xenon Medical Center for emergency microsurgery before their conditions become fatal; the player assumes the role of a member of the surgical staff.