In a struggle to stay alive on this harsh terrain filled with deadly creatures, soldiers who were previously on Motherbase now must work cooperatively in order to survive.

Survive takes place during an alternate timeline immediately following the conclusion of Ground Zeroes, with Big Boss leaving behind a destroyed Mother Base — as well as a group of soldiers who are now stranded in the remains.

A wormhole opens up and ports them into a deserted, transformed version of Ground Zeroes’ setting, one plagued by disturbing creatures whom were biologically damaged during the move across time.