Now you can choose your favorite heroes from the worlds of Street Fighter and Marvel Super Heroes to face off in a head-to-head battle for supremacy. Dive into the action to perform outrageous moves and link together amazing Chain Combos... then delight in their devastating results! Marvel Super Heroes vs. Street Fighter combines two incredible universes to create an entirely new legend of heroic proportions.

Apocalypse re-appears in the game as a sub-boss; after defeating him, your team will face a mechanized, super powered form of Akuma called Cyber-Akuma (Mech-Gouki in the Japanese version). Although the fight is two against one, he makes up for it by having overpowered strength and speed. The character that can beat Cyber-Akuma will have his or her ending viewed upon completion.