Mario & Wario is a puzzle game that is compatible with the SNES Mouse. The player chooses Princess Peach, Mario or Yoshi, and Wario proceeds to drop a bucket on their head (the object changes in later levels). The player controls Wanda the fairy to guide the now-blinded character through an obstacle course, to reach Luigi waiting at the end.

One day, Mario, Luigi, Peach and Yoshi came to the Fairy's Forest in search of its fabled fairy of fortune, but Luigi got lost, causing the other three to get separated. Suddenly, a bucket landed on Mario's head, blocking his eyesight. The perpetrator was Wario, up high and out of reach in his personal plane, the Bulldog. The elusive fairy, Wanda, witnessed this crooked event and vowed to somehow reunite Mario and the team with Luigi.