Loaded is a violent, bloody top-down shooter which places you in the boots of one of six characters, who are all strange and deformed, from a psychotic clown to a huge baby. Loaded is a mission based game, where you have to complete various objectives, such as "escape the prison." Throughout each mission, there are tons of enemies to kill. You can choose to play through the single player campaign, or you can go head to head in two player.

The six playable characters are all psychotic criminals who have been setup by F.U.B., a former catering officer with the Sector Marines. They are now serving sentence on an inhospitable prison planet, the planet Raulf. The player have to escape Raulf, chase F.U.B. and engage on a bloody odyssey across the strange worlds of the galaxy to exact revenge on F.U.B.