Katawa Shoujo is a bishoujo-style visual novel set in the fictional Yamaku High School for disabled children, located somewhere in modern Japan. Hisao Nakai, a normal boy living a normal life, has his life turned upside down when a congenital heart defect forces him to move to a new school after a long hospitalization. Despite his difficulties, Hisao is able to find friends—and perhaps love, if he plays his cards right. There are five main paths corresponding to the 5 main female characters, each path following the storyline pertaining to that character.

Hisao Nakai is an ordinary High school student that, one day, suffers from a heart attack in an awkward situation. When his doctor and parents tell him his disability and the fact that they moved him to the Yamaku Academy, an academy especially designed to educate "people with disabilities", he thinks that his life is finally over.

Guide Hisao Nakai in this new step of his life doing the correct decisions. Who knows, maybe you'll end up in love again...