Kabus 22 is a horror–action game set in Kadiköy district in Istanbul. The player takes control of three characters; the Turkish soldier Demir, his girlfriend Ebru and the mysterious Inzar. These characters have to fight against a despot religious order and creatures which are named Maduns in an alternate near future.

The story of this game tells about the year 2000 when most of the people became servants to a mysterious cult lead by a man called Messiah. At the same time, the world (at least, Turkey, where the game takes place) is infiltrated by strange creatures. The protagonists try to understand the connection between the cult and the monsters in typical Resident Evil fashion – which means, dispatching the enemies and solving puzzles to progress further. Most problems are of "find a key or other way to open the door" kind, though some tasks are of more intricate kind.

The action switches between 3 characters. Demir and Ebru are primarily using hand weapons (though can also perform melee attacks to push enemies away). Inzar excels in magic and martial arts - he employs two blades on his wrists to serve justice to the monsters.