Just Keep Running is a parkour puzzle-platformer that combines freerunning with quick puzzles and problem-solving. Gameplay is said to be inspired by Mirror's Edge, Portal and Ultrakill, with voxel graphics inspired by Teardown, The Touryst, and Cloudpunk.

The story seems to take place in the future, with dates in-game indicating that the story is set in the early 22nd century. The player takes the role of a superhuman person trained to become a supersoldier for Panthera, a futuristic authoritarian government. The player is later tasked with escaping the laboratory and testing facilities they find themselves trapped in, with the help of an underground rebellion group.