Hana Yori Dango: Koi Seyo Otome is a Nintendo DS game based off the anime Hana Yori Dango.

The user plays as a new student at Eitoku Academy, who befriends Tsukushi Makino. Eventually, the player can date the F4 members, Tsukasa Domyoji, Rui Hanazawa, Sojiro Nishikado, and Akira Mimasaka.