GuitarFreaks 10th Mix is a game in the popular GuitarFreaks series of music video games from Konami. The machine can be played by one or two players, and can also be linked with DrumMania 9th Mix. This version features 30 new hit songs with difficult moves.

Gameplay remains the same from previous titles, with the player using a simulated guitar controller to play the notes of a chosen songs guitar part as they are displayed on the screen.