Grief Syndrome is an action game based on popular anime "Mahou Shoujo Madoka Magika." There are five girls to choose from, and each comes with different arsenal. This game combines anime-style with hand drawn with pastel colour for background. RPG elements are also included where characters can raise their level. Another interesting feature is combo system and rewards that can be unlocked if meet certain conditions.

Five magical girls enter a witch's ward.

They defeat messengers and witches to raise their level and defeat the final boss, "Walpurgis Night."