Godzilla: Save the Earth is a fighting video game released in 2004 for the PlayStation 2. It was the first Godzilla title to be released for both the PlayStation 2 and Xbox game consoles. Based on characters and situations from the Godzilla film series, the game itself is the sequel to Godzilla: Destroy All Monsters Melee, released for the GameCube and Xbox in 2002. Godzilla: Save the Earth is followed by Godzilla: Unleashed in 2007 for the PlayStation 2 and the Wii.

Save the Earth takes place two years after Godzilla: Destroy All Monsters Melee. The story involves mankind getting hold of Godzilla's DNA, known in the game as "G-Cells." The Vortaak learn of this, once again returning to Earth, controlling a vast army of monsters, including their ultimate weapon: SpaceGodzilla. The player faces down many controlled monsters in different locations. In the climax cut-scene, Godzilla confronts SpaceGodzilla in a final duel. Godzilla blasts off SpaceGodzilla's shoulder crystals causing a black hole to form. SpaceGodzilla is sucked in and apparently killed, forcing the Vortaak to retreat while Godzilla lets out a victorious roar, having saved the Earth yet again.