E008 is a first-person survival horror game that explores pain and bliss; a game about what a person is willing to do to achieve happiness. Navigate the halls of the laboratory where you are being held, find out the truth about the experiments, and find your missing sibling before you get out. The game focuses heavily on story as well as exploration and will have you fleeing from dangers both real and imagined, although just as baneful.

The player character, refered to as Eight, finds themself in a hidden experimental facility following the disappearance of their brother. While in the process of being put through an experimental drug trial, Eight has to find their brother and flee the facility before the creeping darkness of withdrawal takes them.