Dr. Franken II is a side-scrolling platformer what places you in control of a Frankenstein-like character named Franky. The goal is collect different objects within different levels to put something back together. In order for Franky to recharge his health, you need to find the parts to fix the electricity machine that does it. You will also be taken to exotic locales such as Egypt and the bottom of the ocean to find pieces of Bitsy's golden tablet.

Like its predecessor, there are many trap doors, monsters, and other obstacles that need to be overcome. Keys are needed to unlock new areas of the game, which can be found in the far reaches of the level.

It is many years since Dr. Von Frankenbone passed on and Franky is in big trouble again! The late Doctor's castle, where Franky had spent many happy years with his girlfriend Bitsy, is crumbling and badly in need of repair. If this problems weren't already enough, the electricity company have finally caught up with him and presented him with a huge bill. Franky's only hope is to find the late Doctor's lost treasure; a golden tablet depicting the image of Bitsy, famed throughout the land, but now scattered and lost.

Drastic situations call for drastic measures! Franky has fled Von Frankenbone's Castle and is sheltering in the Doctor's hidden Chateau. Unhappy at the thought of an uncontrolled monster on the loose, the local villagers have locked him in. It is your quest (as Franky) to search the Chateau for clues to the whereabouts of the lost fortune and to escape captivity so that you may search the estate grounds and beyond, from the depths of the ocean to the pyramids of Egypt. Only after much traveling may you return to pay off your debts.

Franky is back - with new levels and new challenges, but hurry . . . time is running out!!