Digital Holmes is an adventure game released in 2001 by Arc System Works. It is a PlayStation 2 exclusive title.

In the game, descendants of Sherlock Holmes and Dr. Watson have changed professions and must solve a case within 48 hours. During the investigation, there are negotiation scenes known as "Tactical Talk," where players choose dialogue options to persuade others and gain an advantage in the investigation. Each character also has an affection level, and as this value increases, various events can be triggered.