The first entry in the D series and one of the first games released by the company, it dealt with taboo content such as violence and cannibalism, featured 3D CGI full-motion video and a first-person perspective. It was the first game to star the digital actress, Laura.

The game begins when Laura Harris is contacted by the Los Angeles police, receiving a disturbing message: her father, Dr. Richter Harris, has gone on a mass murdering spree and barricaded himself in the hospital. Laura rushes to the scene of the crime, desperate to find an explanation for the well-respected doctor's actions. Upon entering the hospital, she is so horrified at the murdered bodies lying about the halls that she covers her eyes. When she uncovers them again in the 3DO version, she finds herself in an unknown dark castle. In later versions of the game, she is still in the hospital and explores further, until taken by a small metallic entity to the castle.

Unwilling to give up her search, Laura continues through the dark corridors of the medieval hall. While attempting to find her father, she experiences a series of flashbacks of her mother being stabbed to death. Laura's father (taking the form of apparitions) warns her to leave, saying that staying too long means being stuck in the alternate reality forever. He warns that he will soon become an emotionless monster and will eventually try to kill her. Still shaken, Laura proceeds to find her father residing at the peak tower of the castle. Angrily, the father reveals the sordid past of his family: Laura and her father are part of a bloodline with an insatiable appetite for human flesh, dating back to the infamous Dracula. Laura had killed and eaten her mother years ago, but it was erased from her memory by her father. As Dr. Harris begins to transform into a vampire, Laura has to make a choice: kill or be killed. There are four endings available depending on the players' actions at the end.