Crash Bandicoot: Mutant Island is an 2D action platform game for mobile phones based on the better known 3D action platform game. The game starts with Crash's sister Coco being kidnaped by Cortex. Crash hurries to save his sister and confronts cortex and his giant robot. In the battle that follows, Coco manages to escape but upon return they realise it was all a distraction to kidnap and hypnotize the other Bandicoots.

Crash is sleeping, but is alarmed when an unknown bandicoot wakes up Crash to alert him that his sister, Coco Bandicoot has been kidnapped by Doctor Neo Cortex. Crash ventures through the jungle until he eventually catches up to Cortex, who is using a machine to destroy Crash. Just as Crash was about to defeat Cortex, Cortex smashed Crash leading him to the ground, where he is told that Coco escaped and returned back home. When returning back home, Coco sees headphones and suspects that Cortex has imprisoned the animals, and Crash was going to another adventure to defeat Cortex and free the Hypnotized Bandicoots from Cortex. Exploring three different islands to discover the Cortex flying castle in this high-speed adventure, along the way Crash will have to find and take control of the Three Legendary Titans of the three Mutant Islands. Once the missing marsupials are freed, defeated the mutants that blocked his way to the flying Cortex Castle and gained the support of the Three Legendary Titans, Crash will once again come face to face with the Cortex robot. Once defeated, Crash will be welcomed triumphantly by the bandicoot tribe with a big party.