Cosmo Warrior Zero, originally created and supervised by Reiji Matsumoto, a game combining an action/shooting game and a digital comic! A game with 3 modes that invite the player into a new "Matsumoto World"!

It's the end of the 30th century. Humanity is reaching as far as Andromeda, but the mechanized beings that humanity created become rogue and conquer their creators, enslaving humanity. Those who don't want to suffer their control have fled Earth.

Zero is one of these men. He is a commander of the independent Fleet, what remains of the armed forces of Earth. The war against humanoids left him without family and now his only motivation is to fight the mechanical men, but he receives an order from the supreme commander: to hunt a space pirate called Captain Harlock, who is said to be allied with the mechanical men.

Zero faces a difficult situation, as Harlock was the one who trained him and he only assaults the ships of the mechanical men. Determined to find the truth, Zero accepts the mission.

After having his wife and child disappear in the battle between the humans and Machine men, Zero has no choice but to serve Earth's government as Captain of second rate ships. After picking up a SOS signal, Zero soon meets Harlock who blows up several cargo ship and destroys Zero's own. After coming back to Earth, Zero is given a new task of hunting down the space pirate Harlock with his new crew of machine men and humans in his old ship, the Karyu.

Zero is often faced with problems between the machine men and the humans on his ship who always seem to fight, often causing problems. After meeting Harlock, Zero has more of an appreciation towards him and stills believes in him even after he sees him attack civilians. Later on in the series, Zero and his first officer Marina Oki grow feelings for each other and end up falling in love.