Momoko Sakura is an elementary school student who likes popular idol Momoe Yamaguchi and mangas. She is often called "Chibi Maruko-chan" due to her young age and small size. She lives together with her parents, her grandparents and her elder sister in a little town. In school, she has many friends with whom she studies and plays together everyday, including her close pal, Tama-chan; the student committee members, Maruo-kun and Migiwa-san; and the B-class trio: 'little master' Hanawa-kun, Hamaji-Bu Taro and Sekiguchi-kun. This is a fun-loving and enjoyable anime that portrays the simple things in life.

Chibi Maruko-Chan - Maruko Enikki World is an interactive comic game that features 4 different stories with japanese voice acting of all the characters.

The gameplay as is usual in the interactive comics is make the story advance by clicking in different items or characters that are in the screen.