Chaos Break is a third-person shooting game, with echoes of survival horror such as Resident Evil. Set in an abandoned biochemical laboratory on an isolated island, the two player characters, Mitsuki and Rick, are part of an investigatory and cleansing force sent to find out the cause of an 'anomalous thermal reaction'. This game is a spin-off, set in the same universe as the arcade game Chaos Heat.

Set in an abandoned, contaminated biochemical laboratory; Fluxus Biomateril Industries Lab 7, a civilian research facility set on an isolated island. The two playable characters; Mitsuki and Rick, who are D.E.F agents, an investigatory and cleansing task force that are sent out to check the facility, and retrieve the research data.