Chameleon Twist is a 3D-Jump & Run, developed by Japan System Supply and released by Sunsoft in 1997.

After following a rabbit into a magical hole in the ground, the blue chameleon named Davy realises that he has taken on a humanoid form. In an attempt to find a way back home, Davy is traveling throughout six lands with his friends, Jack, Fred, and Linda; together they discover Jungle Land, Ant Land, Bomb Land, Desert Castle, Kids Land, and Ghost Castle to find the certain magic portal.

The protagonist of the game is a blue chameleon named Davy who, upon following a rabbit (closely resembling Lewis Carroll's White Rabbit) into a magical hole in the ground, finds he has taken on a humanoid form.

The plot involves Davy or one of his friends, Jack, Fred, or Linda, traveling throughout the six lands of the magic portal he enters, in an attempt to find a way back through the portal and back home, following the same rabbit he met before he entered the world.